Hypervariable allelic expression patterns of the imprinted IGF2 gene in tumor cells
✍ Scribed by He, Liangme; Cui, Hengmi; Walsh, Colum; Mattsson, Ragnar; Lin, Weili; Anneren, Göran; Pfeifer-Ohlsson, Susan; Ohlsson, Rolf
- Book ID
- 110061071
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 563 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0950-9232
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Several human imprinted genes have been identified and are implicated in genetic diseases and tumorigenesis. We studied alterations of two imprinted genes, the paternally imprinted H19 and maternally imprinted IGF2, in 15 ovarian tumors with various cell types. To know allele-specific expression of
## Abstract Loss of imprinting (LOI) of insulin‐like growth factor 2 (__IGF2__) is a common event in many cancers and typically activates the maternally silenced allele. The resulting biallelic __IGF2__ expression correlates strongly with the hypomethylation of a differentially methylated region (D