Hypervalent Iodine(III) Promoted Direct Synthesis of Imidazo[1,2- a ]pyrimidines
β Scribed by Qian, Guangyin; Liu, Bingxin; Tan, Qitao; Zhang, Siwen; Xu, Bin
- Book ID
- 127324354
- Publisher
- John Wiley and Sons
- Year
- 2014
- Tongue
- English
- Weight
- 268 KB
- Volume
- 2014
- Category
- Article
- ISSN
- 1434-193X
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π SIMILAR VOLUMES
The synthesis of imidazo [1,2-a]pyridine and imidazo[1,2-a]pyrimidine derivatives by condensation between an a-bromoketone bound to solid support and various 2-aminopyridine or 2-aminopyrimidine derivatives was described. Either an acid labile linker or a base labile linker was used in this study.
## Abstract Simple stirring of a mixture of the alkynyl(phenyl)iodonium salts **1** with 2βaminopyrimidine **2** in chloroform under reflux for two hours in the presence of K~2~CO~3~ gave, after workup, the 2βsubstituted imidazo[1,2βΞ±]pyrimidines **3** in moderate to good yields. A possible mechani
## Abstract For Abstract see ChemInform Abstract in Full Text.