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Hypervalent Iodine(III) Promoted Direct Synthesis of Imidazo[1,2- a ]pyrimidines

✍ Scribed by Qian, Guangyin; Liu, Bingxin; Tan, Qitao; Zhang, Siwen; Xu, Bin


Book ID
127324354
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
268 KB
Volume
2014
Category
Article
ISSN
1434-193X

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Solid-phase synthesis of imidazo[1,2-a]p
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The synthesis of imidazo [1,2-a]pyridine and imidazo[1,2-a]pyrimidine derivatives by condensation between an a-bromoketone bound to solid support and various 2-aminopyridine or 2-aminopyrimidine derivatives was described. Either an acid labile linker or a base labile linker was used in this study.

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## Abstract Simple stirring of a mixture of the alkynyl(phenyl)iodonium salts **1** with 2‐aminopyrimidine **2** in chloroform under reflux for two hours in the presence of K~2~CO~3~ gave, after workup, the 2‐substituted imidazo[1,2‐α]pyrimidines **3** in moderate to good yields. A possible mechani