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Solid-phase synthesis of imidazo[1,2-a]pyridines and imidazo[1,2-a]pyrimidines

✍ Scribed by Saı̈d El Kazzouli; Sabine Berteina-Raboin; Abderrahim Mouaddib; Gérald Guillaumet

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 409 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)01532-6

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✦ Synopsis

The synthesis of imidazo [1,2-a]pyridine and imidazo[1,2-a]pyrimidine derivatives by condensation between an a-bromoketone bound to solid support and various 2-aminopyridine or 2-aminopyrimidine derivatives was described. Either an acid labile linker or a base labile linker was used in this study.

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