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Hypervalent Iodine Reagents for the Oxidation of Alcohols and Their Application to Complex Molecule Synthesis

✍ Scribed by Hirofumi Tohma; Yasuyuki Kita

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
424 KB
Volume
346
Category
Article
ISSN
1615-4150

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✦ Synopsis

Abstract

Hypervalent iodine(V) derivatives such as 2‐iodoxybenzoic acid (IBX) and Dess–Martin periodinane [DMP; 1,1,1‐tris(acetyloxy)‐1,1‐dihydro‐1,2‐benziodoxol‐3‐(1__H__)‐one] have been used widely for the oxidation of alcohols to aldehydes and ketones during the last decade because of their high chemoselectivity, mild reactivity, and high yielding process. This review focuses on the recent progress in the oxidation of alcohols to carbonyl compounds using IBX, DMP, and other hypervalent iodine reagents, and their application to total syntheses of a variety of complex natural products.

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