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Hypertonic stimulation induces synthesis and release of glutamate in cultured rat hypothalamic astrocytes and C6 cells

โœ Scribed by Rong Cao; Shan Jiang; Li Duan; Ying-Fei Xiong; Bei Gao; Zhi-Ren Rao


Book ID
107639180
Publisher
Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Year
2008
Tongue
English
Weight
1007 KB
Volume
24
Category
Article
ISSN
1673-7067

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## Abstract Nitric oxide (NO; 1 ฮผM) or an NO donor (500 ฮผM diethylenetriamineโ€nitric oxide, DETAโ€NONOate) caused rapid glutamate and ATP release from cultured rat cortical astrocytes. NOโ€induced glutamate release was prevented by calcium chelators (EGTA or BAPTAโ€AM) and an inhibitor of vesicular ex