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Hyperthermic induction of apoptosis in malignant fibrous histiocytoma cells: possible involvement of a p53-independent pathway in the induction ofbaxgene

✍ Scribed by Masato Yonezawa; Takanobu Otsuka; Taiji Kato; Akihiko Moriyama; Kohichi H. Kato; Kiyofumi Asai; Nobuo Matsui


Book ID
107707835
Publisher
Springer Japan
Year
2002
Tongue
English
Weight
135 KB
Volume
7
Category
Article
ISSN
0949-2658

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## Abstract A p53 C‐terminal peptide (aa 361–382, p53p), fused at its C‐terminus to the minimal carrier peptide of __antennapedia__ (17 aa, Ant; p53p‐Ant), induced rapid apoptosis in human cancer cells, __via__ activation of the Fas pathway. We examined p53p‐Ant mechanism of action, toxicity in var