Hyperthermia-induced exencephaly in mice: Effect of multiple exposures
โ Scribed by Chernoff, G. F. ;Golden, J. A.
- Book ID
- 112217795
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 535 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-3709
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๐ SIMILAR VOLUMES
The present study shows that the multifactorial genetic liability to spontaneous exencephaly in the SELH/Bc mouse strain (10-20% of embryos) also confers an elevated risk of exencephaly induced by valproic acid. Treatment of pregnant dams (600 mg/kg sodium valproate in distilled water, i.p.) during
Neural tube defects (NTDs) are among the most common congenital malformations, affecting approximately 1 per 1,000 liveborn infants in the United States . Maternal exposure to hyperthermia, either through recreational sources or due to an infectious agent, is thought to account for approximately 10%