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Hyperprolactinemia is an indicator of progressive disease and poor prognosis in advanced breast cancer

✍ Scribed by Wilhelm Holtkamp; Gerd Arno Nagel; Hans-Erik Wander; Helmut Franz Rauschecker; Dorit Von Heyden

Publisher
John Wiley and Sons
Year
1984
Tongue
French
Weight
573 KB
Volume
34
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

In a long‐term follow‐up study, prolactin levels were measured in 149 patients with advanced metastatic breast cancer. Control groups included 221 patients with primary operable breast cancer and 150 women with benign breast disease. Hyperprolactinemia (>1,000 mlU/l; HYPRL) occurs in 44% of patients with metastatic breast cancer in the course of the disease (p<0.001 compared to patients with non‐metastatic disease). HYPRL is associated with progressive breast cancer in 88% of cases. In patients experiencing several episodes of disease remission and relapse, incidence of HYPRL increases with each relapse. Prolactin blood levels return to normal if hyperprolactinemic patients experience remission after chemotherapy. Patients expressing HYPRL have a shorter survival time after mastectomy when compared to patients who never developed HYPRL (154/89 months, p= 0.01). It is concluded that HYPRL is of prognostic significance and a reliable indicator of progressive disease in advanced metastatic breast cancer.

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