A mother and five of her ten offspring developed colonic cancers, the mother and one of the offspring being younger than 50 years of age at diagnosis. Despite fulfilling the Amsterdam criteria for hereditary non-polyposis colorectal cancer (HNPCC), several features pointed towards the possibility th
Hyperplastic Polyposis and the Risk of Colorectal Cancer
β Scribed by Neil H. Hyman; P. Anderson; H. Blasyk
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 70 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0012-3706
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Hereditary non-polyposis colorectal cancer (HNPCC) is known to be associated with several extracolonic cancers, e.g., cancers of the endometrium, stomach, urinary tract, small bowel and ovary. An association between HNPCC and brain tumours has also been reported, although previous risk analysis did
Identification of hereditary non-polyporis colorectal cancer (HNPCC) indicates theoretical life-time risks of 50% for the descendants of an affected family member and of 100% for the true gene carriers. However, besides colorectal cancer (CRC), many other cancer types and sites are also involved, wh
Prophylaxis advocated