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Hyperplasia, partial hepatectomy, and the carcinogenicity of aflatoxin B1

✍ Scribed by B.D. Roebuck

Book ID: 102302520
Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 103 KB
Volume: 91
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.10758

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✦ Synopsis

Abstract

Generalized cellular hyperplasia has long been associated as a factor in the causation of liver cancer. Parenchymal cell hyperplasia resulting from hepatotoxins, viruses, parasites, or malnutrition is exceedingly variable as to when it occurs, its extent, and its duration. Partial hepatectomy has been used as an experimental tool precisely because the timing and extent of hyperplasia can be known and controlled. With regards to aflatoxin B~1~ (AFB~1~) carcinogenesis, partial hepatectomy has produced variable results. An explanation appears to reside in the hepatotoxic properties of AFB~1~ that enhance the early stages of carcinogenesis. © 2003 Wiley‐Liss, Inc.

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