An enantioselective formal synthesis of the proteasome inhibitor (+)-lactacystin has been achieved using an alkylidene carbene 1,5-CH insertion reaction as a key step. The key cyclisation precursor was synthesised in high diastereomeric excess using a combination of known procedures, with the two ke
✦ LIBER ✦
Hypericin—an inhibitor of proteasome function
✍ Scribed by F Pajonk; J Scholber; B Fiebich
- Book ID
- 105992082
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 376 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0344-5704
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