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Hyperhomocysteinaemia in treated patients with Huntington's disease homocysteine in HD

✍ Scribed by Jürgen Andrich; Carsten Saft; Anneliese Arz; Birgit Schneider; Markus W. Agelink; Peter H. Kraus; Wilfried Kuhn; Thomas Müller

Book ID
102944301
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
542 KB
Volume
19
Category
Article
ISSN
0885-3185

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✦ Synopsis

Significantly increased plasma total homocysteine levels (t-Hcys) appeared in treated Huntington disease (HD) patients compared to controls and untreated HD subjects. Because the protein Huntingtin interacts with the homocysteine metabolism modulating enzyme cystathionine beta-synthase, we hypothesize that homocysteine promotes neurodegeneration in HD.

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