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Hyperfunctioning Thyroid Adenoma and Activating Mutations in the TSH Receptor Gene

โœ Scribed by Michel Polak


Book ID
114180237
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
35 KB
Volume
30
Category
Article
ISSN
0188-4409

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The gene for the alpha polypeptide chain (alpha s) of the heterotrimeric G protein Gs can be activated to the putative oncogene gsp by specific point mutations at codons 201 and 227. Such mutations have been reported in 40% of human growth hormone-secreting pituitary adenomas and in a single autonom