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Thyrotropin receptor gene mutations and TSH resistance: variable expressivity in the heterozygotes

✍ Scribed by Marta Camilot; Francesca Teofoli; Alberto Gandini; Roberto Franceschi; Anna Rapa; Andrea Corrias; Gianni Bona; Giorgio Radetti; Luciano Tatò


Book ID
108703216
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
253 KB
Volume
63
Category
Article
ISSN
0300-0664

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Variable expressivity and mutation datab
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For over 50 years genetics has presumed that variations in phenotypic expression have, for the most part, been the result of alterations in genotype. The importance and value of mutation databases has been based on the premise that the same gene or allelic variation in a specific gene that has been