Burkitt's lymphoma cells that vary in their phenotypic characteristics show significantly different degrees of susceptibility to radiation-induced apoptosis. Propensity to undergo apoptosis is reflected in the degradation of substrates such as DNA-dependent protein kinase but the status of bcl-2, c-
Hydroxyurea induces apoptosis and regular DNA fragmentation in a Burkitt's lymphoma cell line
β Scribed by Catherine A. Johnson; Trevor H. Forster; Clay M. Winterford; David J. Allan
- Book ID
- 119121514
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 273 KB
- Volume
- 1136
- Category
- Article
- ISSN
- 0167-4889
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract EpsteinβBarr virus (EBV) infects more than 90% of the human population and has a potential oncogenic nature. Trichostatin A (TSA) has potent antitumor activity, but its exact mechanism on EBVβinfected cells is unclear. This study examined the effects of TSA on proliferation and apoptosi
## Abstract Hydroxyurea (HU), as an inhibitor of ribonucleotide reductase (RR) through interaction with the R2 component, has been used in the treatment of malignancies. Recently, therapeutic strategies in EpsteinβBarr Virus (EBV)βtargeted lymphoma have been reported. In order to study the effect o