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Flavopiridol Induces Apoptosis and Caspase-3 Activation of a Newly Characterized Burkitt's Lymphoma Cell Line Containing Mutant P53 Genes

✍ Scribed by Aaron P. Rapoport; Michelle Simons-Evelyn; Timothy Chen; Rochel Sidell; Shannon Luhowskyj; Karen Rosell; Tom Obrig; David Hicks; Patricia M. Hinkle; Moon Nahm; Richard A. Insel; Camille N. Abboud

Book ID
115590153
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
328 KB
Volume
27
Category
Article
ISSN
1079-9796

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## Abstract Epstein–Barr virus (EBV) infects more than 90% of the human population and has a potential oncogenic nature. Trichostatin A (TSA) has potent antitumor activity, but its exact mechanism on EBV‐infected cells is unclear. This study examined the effects of TSA on proliferation and apoptosi