Hydroxamamide as a chelating moiety for the preparation of 99mTc-radiopharmaceuticals III. Characterization of various 99mTc-hydroxamamides
β Scribed by M. Nakayama; L.C. Xu; Y. Koga; K. Harada; A. Sugii; H. Nakayama; S. Tomiguchi; A. Kojima; Y. Ohyama; M. Takahashi; I. Okabayashi
- Book ID
- 108484382
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 449 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0969-8043
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An improved method for the preparation of 99mTc-radiopharmaceuticals containing the TEN multiple bond, in sterile and apyrogen conditions, is described. This method is based on the reaction of [99mTc]pertechnetate with ligands derived from S-methyl dithiocarbazate [H2N--N(R)~C(=S)SCH 3 (R = H, CH3]
## Abstract A novel and efficient method for preparing ^99m^Tcβcomplexes of radiopharmaceuticals has been developed by reacting [^99m^Tc]pertechnetate with a ligand in the presence of borohydride exchange resin (BER) as a reducing agent. The latter is stable over a wide range of pH (2β11) and thus