The solubilizing ability of two aromatic hydrotropes, N,N-diethylnicotinamide (DENA) and N,N-dimethylbenzamide (DMBA), was investigated using a set of 13 poorly soluble, structurally diverse drugs. The number of aromatic rings in the solute molecule has a very strong effect on the solubility enhance
Hydrotropic Solubilities
โ Scribed by Booth, Harold Simmons; Everson, Howard E.
- Book ID
- 120507645
- Publisher
- American Chemical Society
- Year
- 1950
- Weight
- 283 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0019-7866
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๐ SIMILAR VOLUMES
Hydrotropes are a class of amphiphilic molecules that cannot form well organized structures, such as micelles, in water but do increase the aqueous solubility of organic molecules. Often strong synergistic effects are observed when hydrotropes are added to aqueous surfactant or polymer solutions. Re
## Hydrotropes Stig E Friberg Previous views on hydrotropic solubilization as a matter of pair wise complexation between solubilizate and hydrotrope molecule have become modified during the past year. Three main discoveries concerning hydrotropes have been made: first, vapor pressures of solubiliz