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Hydrophobic patches on the surfaces of protein structures

โœ Scribed by Philip Lijnzaad; Herman J. C. Berendsen; Patrick Argos

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
689 KB
Volume
25
Category
Article
ISSN
0887-3585

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โœฆ Synopsis

A survey of hydrophobic patches on the surface of 112 soluble, monomeric proteins is presented. The largest patch on each individual protein averages around 400 A2 but can range from 200 to 1,200 A2. These areas are not correlated to the sizes of the proteins and only weakly to their apolar surface fraction. Ala, Lys, and Pro have dominating contributions to the apolar surface for smaller patches, while those of the hydrophobic amino acids become more important as the patch size increases. The hydrophilic amino acids expose an approximately constant fraction of their apolar area independent of patch size; the hydrophobic residue types reach similar exposure only in the larger patches. Though the mobility of residues on the surface is generally higher, it decreases for hydrophilic residues with increasing patch sue. Several characteristics of hydrophobic patches catalogued here should prove useful in the design and engineering of proteins.

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