Hydrophobic core packing and protein design

✍ Scribed by Greg A Lazar; Tracy M Handel

• Book ID: 104415085
• Publisher: Elsevier Science
• Year: 1998
• Tongue: English
• Weight: 669 KB
• Volume: 2
• Category: Article
• ISSN: 1367-5931
• DOI: 10.1016/s1367-5931(98)80102-6

✦ Synopsis

Over the past few years, we have witnessed exciting advances in protein design. Several groups have reported success in the design of hydrophobic cores, and the principles developed in these studies have been recently applied to the full sequence design of a small protein motif and the design of a catalytically active metal center. These successes suggest that designing large, functional proteins in computero is more feasible than ever before.