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Hydrophilic biodegradable microspheres of interferon-alpha and its pharmacokinetics in mice

✍ Scribed by Cai-Hong Zheng; He-Yong Yu; Jian-Qing Gao; Xiao-Yi Sun; Wen-Quan Liang

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
193 KB
Volume
85B
Category
Article
ISSN
1552-4973

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✦ Synopsis

Abstract

The goal of this research was to prepare a kind of hydrophilic sustained release microspheres of interferon‐alpha (IFN‐α), alginate‐chitosan microspheres (ACM) of IFN, and investigate its pharmacokinetics in mice. Alginate microspheres of IFN‐α were first prepared by an emulsion method and further incubated in chitosan to form IFN‐ACM. The influences of isopropanol, bovine serum albumin (BSA), and pH adjustment by isoelectric point of IFN were studied. The optimized IFN‐ACM was obtained with smooth and round morphology, size of 2.18 ± 0.43 μm and entrapment efficiency of 40%. All the concentrations of IFN‐α were determined by IFN assay kits. Finally the pharmacokinetics of IFN‐ACM suspension was studied in ICR mice by intramuscular (I.M.) routes. Compared with IFN solution, C~max~ of IFN‐ACM reduced 2.3‐fold, and time to achievement of maximum serum concentrations (T~max~) increased 4‐fold. Meanwhile the area under the concentration‐time curve (AUC) was the same as that of solution. The concentration‐time profiles presented the prolonged serum levels of IFN from IFN‐ACM. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008

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