Hydrogen Peroxide Induces Lysosomal Protease Alterations in PC12 Cells
β Scribed by Daniel C. Lee; Ceceile W. Mason; Carl B. Goodman; Maurice S. Holder; Otis W. Kirksey; Tracy A. Womble; Walter B. Severs; Donald E. Palm
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 508 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0364-3190
No coin nor oath required. For personal study only.
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Direct exposure of human hepatoma cell line SMMC-7721 to hydrogen peroxide (H2O2) can induce apoptosis. Apoptosis induced by H2O2 was inhibited by cycloheximide, actinomycin D, 3-aminobenzamide, EGTA or Zn2+. H2O2 can increase the level of intracellular Ca2+, downregulate GSH levels, slightly induce