Recent experiments have presented evidence that Watson-Crick hydrogen bonds in a base pair are not absolute requirements for efficient synthesis of that pair by DNA polymerase enzymes. Here we examine quantitative steady-state kinetic data from several published studies involving poorly hydrogen-bon
โฆ LIBER โฆ
HYDROGEN BONDING, BASE STACKING, AND STERIC EFFECTS IN DNA REPLICATION
โ Scribed by Kool, Eric T.
- Book ID
- 115546980
- Publisher
- Annual Reviews
- Year
- 2001
- Tongue
- English
- Weight
- 336 KB
- Volume
- 30
- Category
- Article
- ISSN
- 1056-8700
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This review summarizes results concerning molecular interactions of nucleic acid bases as revealed by advanced ab initio quantum chemical (QM) calculations published in last few years. We first explain advantages and limitations of modern QM calculations of nucleobases and provide a brief history of