Recent experiments have presented evidence that Watson-Crick hydrogen bonds in a base pair are not absolute requirements for efficient synthesis of that pair by DNA polymerase enzymes. Here we examine quantitative steady-state kinetic data from several published studies involving poorly hydrogen-bon
β¦ LIBER β¦
Selectivity of DNA Replication: The Importance of Base-Pair Geometry over Hydrogen Bonding
β Scribed by Ulf Diederichsen
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 154 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0044-8249
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In a recent experimental study, it was reported that replacement of thymine in the adenineαthymine base pair of DNA by its molecular analogs which Ε½ . cannot form proper hydrogen bonds with adenine A does not cause disruption of DNA structure and synthesis. AM1 and ab initio molecular orbital calcul