Hydride Generation Graphite Furnace Atomic Absorption Determination of Bismuth in Clinical Samples with in Situ Preconcentration

✍ Scribed by H. Matusiewicz; M. Kopras; A. Suszka

• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 447 KB
• Volume: 52
• Category: Article
• ISSN: 0026-265X
• DOI: 10.1006/mchj.1995.1099

✦ Synopsis

A sensitive method for the determination of bismuth in clinical samples using hydride generation/ trapping and atomization in a graphite furnace is described. Addition of (\mathrm{Pd}-\mathrm{Ir}) to the furnace tube surface before hydride trapping leads to great improvement in the sensitivity of the method. Calibration is achieved with simple aqueous standards carried through this same procedure. An absolute detection limit ((3 \sigma)) of (100 \mathrm{pg}) and a concentration detection limit of (20 \mathrm{ng} /) liter are obtained using (5-\mathrm{ml}) sample volumes. Corresponding precisions of 8-12% are typical for analyses of these samples. Microwave-assisted sample digestion procedures using (\mathrm{HNO}{3}) and (\mathrm{H}{2} \mathrm{O}_{2}) were used to decompose clinical materials. The method was used to determine Bi in human blood, serum, urine, and tissue before and after intake of therapeutic doses of colloidal bismuth citrale. tyes Academic Press, Inc.