Hydration and distortion of peptide helices in crystals. α-Helical structure of a dodecapeptide, Boc-(Ala-Leu-Aib)4-OMe
✍ Scribed by KARLE, ISABELLA L. ;FLIPPEN-ANDERSON, JUDITH L. ;UMA, K. ;BALARAM, P.
- Book ID
- 115099594
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Tongue
- English
- Weight
- 596 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0367-8377
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📜 SIMILAR VOLUMES
Leu-Ala-Leu-Aib-OMe, have been obtained. Antiparallel helix aggregation is observed in crystals grown from methanol ( A ) , while completely parallel packing is observed in crystals from isopropanol ( B ) or an ethylene glycol-ethanol mixture ( C ) . Crystals B and C are very similar in molecular co
As models of the helical N-terminal part of alamethicin the undecapeptides Boc-L-Ala-[Aib-Ala]2-Glu(0Bzl)-Ala-[Aib-Ala],-OMe (1) and Boc-~-Ala-[Aib-Ala]~-Gly-Ala-[Aib-Ala]~-OMe (2) were synthesized. 1 was examined by X-ray crystallography using direct methods for solution of the phase problem. The u