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Parallel Packing of α -helices in Crystals of the Zervamicin IIA Analog Boc-Trp-Ile-Ala-Aib-Ile-Val-Aib-Leu-Aib-Pro-OMe· 2H2O

✍ Scribed by Isabella L. Karle, Muppalla Sukumar and Padmanabhan Balaram

Book ID
123633608
Publisher
National Academy of Sciences
Year
1986
Tongue
English
Weight
790 KB
Volume
83
Category
Article
ISSN
0027-8424

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Synthesis of the endothiopeptide BOC-Trp
Synthesis of the endothiopeptide BOC-Trp-Ile-Ala-Aib-Ile-ValΨ[CSNH]Aib-Leu-Aib-Pro-OMe by a variation of the ‘azirine/oxazolone method’
✍ Jürg Lehmann; Anthony Linden; Heinz Heimgartner 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 900 KB

The synthesis of the decaendothiopepfide BOC-Trp-Ile-Ala-Aib-lle-Val~F[CSNH]Aib-Leu -Aib-Pro-OMe is described. The introduction of the thioamide group next to the bulky Aib occurred via a variation of the 'azirine/oxazolone method' without epimerisation. The structure of the decaendothiopeptide was

Helix aggregation in peptide crystals: O
Helix aggregation in peptide crystals: Occurrence of either all parallel or antiparallel packing motifs for α-helices in polymorphs of Boc-Aib-Ala-Leu-Ala-Leu-Aib-Leu-Ala-Leu-Aib-OMe
✍ Isabella L. Karle; Judith L. Flippen-Anderson; K. Uma; P. Balaram 📂 Article 📅 1990 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 722 KB

Leu-Ala-Leu-Aib-OMe, have been obtained. Antiparallel helix aggregation is observed in crystals grown from methanol ( A ) , while completely parallel packing is observed in crystals from isopropanol ( B ) or an ethylene glycol-ethanol mixture ( C ) . Crystals B and C are very similar in molecular co