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Hybrid formation between the intracellular faces of the bradykinin B2 and angiotensin II AT1 receptors and signal transduction

✍ Scribed by Jun Yu; Gregory N Prado; Linda Taylor; Ruma Pal-Ghosh; Peter Polgar

Book ID
117798100
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
588 KB
Volume
2
Category
Article
ISSN
1567-5769

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## Abstract The intracellular (IC) face of the G‐protein coupled receptors (GPCR), bradykinin (BK) B2 and angiotensin (AT) 1a, is similar in sequence homology and in size. Both receptors are known to link to GΞ±i and GΞ±q but differ markedly in a number of physiologic actions, particularly with respe

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## Abstract Bradykinin (BK) and angiotensin II (AngII) often have opposite roles in cardiovascular diseases. Our aim here was to construct hybrid receptors which bind AngII but signal as BK. Various sequences of the intracellular face of the AngII type I receptor, AT1R, were replaced with correspon