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Agonist-independent Nuclear Localization of the Apelin, Angiotensin AT1, and Bradykinin B2 Receptors

✍ Scribed by Lee, D. K.; Lanca, A. J.; Cheng, R.; Nguyen, T.; Ji, X. D.; Gobeil, F.; Chemtob, S.; George, S. R.; O'Dowd, B. F.

Book ID
121883390
Publisher
The American Society for Biochemistry and Molecular Biology
Year
2003
Tongue
English
Weight
961 KB
Volume
279
Category
Article
ISSN
0021-9258

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## Abstract Bradykinin (BK) and angiotensin II (AngII) often have opposite roles in cardiovascular diseases. Our aim here was to construct hybrid receptors which bind AngII but signal as BK. Various sequences of the intracellular face of the AngII type I receptor, AT1R, were replaced with correspon