✦ LIBER ✦

Hybocarpone, a novel cytotoxic naphthazarin derivative from mycobiont cultures of the lichen Lecanora hybocarpa

✍ Scribed by Michael A. Ernst-Russell; John A. Elix; Christina L.L. Chai; Anthony C. Willis; Nobuo Hamada; Thomas H. Nash III

Book ID: 104262003
Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 245 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)01220-4

No coin nor oath required. For personal study only.

✦ Synopsis

Hybocarpone (1), a novel pentacyclic naphthazarin-derived dimer has been isolated from mycobiont cultures derived from the lichen Lecanora hybocarpa. The structure of hybocarpone (1) was established on the basis of 1D and 2D NMR spectroscopy. Its relative stereochemistry was predicted with the use of molecular modelling and confirmed by X-ray crystallographic analysis. Hybocarpone (1) was found to be a potent cytotoxin (IC50 c 0.27 IJM), active against the marine P815 mastocytoma cell line.

📜 SIMILAR VOLUMES

ChemInform Abstract: Hybocarpone, a Nove

ChemInform Abstract: Hybocarpone, a Novel Cytotoxic Naphthazarin Derivative from Mycobiont Cultures of the Lichen Lecanora hybocarpa.

✍ Michael A. Ernst-Russell; John A. Elix; Christina L. L. Chai; Anthony C. Willis; 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 25 KB 👁 2 views

Novel Fluorescent Isoquinoline Pigments,

Novel Fluorescent Isoquinoline Pigments, Panaefluorolines A—C from the Cultured Mycobiont of a Lichen, Amygdalaria panaeola.

✍ Kaoru Kinoshita; Yoshikazu Yamamoto; Kiyotaka Koyama; Kunio Takahashi; Isao Yosh 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 60 KB

A novel aryl-hydrazide from the marine l

A novel aryl-hydrazide from the marine lichen Lichina pygmaea: Isolation, synthesis of derivatives, and cytotoxicity assays

✍ Catherine Roullier; Marylène Chollet-Krugler; Pierre van de Weghe; Françoise Loh 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 320 KB

A new aryl-hydrazide L-glutamic acid derivative, pygmeine (3), was isolated from a methanolic extract of Lichina pygmaea, a marine lichen. Synthetic derivatives obtained via a two-step coupling of L-glutamic acid with phenylhydrazine moieties were useful to elucidate the structure of 3 and to carry

ChemInform Abstract: A Novel Aryl-Hydraz

ChemInform Abstract: A Novel Aryl-Hydrazide from the Marine Lichen Lichina pygmaea: Isolation, Synthesis of Derivatives, and Cytotoxicity Assays.

✍ Catherine Roullier; Marylene Chollet-Krugler; Pierre van de Weghe; Francoise Loh 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 18 KB 👁 2 views

## Abstract A new aryl‐hydrazide (S)‐glutamic acid derivative, pygmeine (Ia), is isolated from the methanolic extract of the title marine lichen.