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A novel aryl-hydrazide from the marine lichen Lichina pygmaea: Isolation, synthesis of derivatives, and cytotoxicity assays

✍ Scribed by Catherine Roullier; Marylène Chollet-Krugler; Pierre van de Weghe; Françoise Lohézic-Le Devehat; Joël Boustie

Book ID: 104004497
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 320 KB
Volume: 20
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.06.013

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✦ Synopsis

A new aryl-hydrazide L-glutamic acid derivative, pygmeine (3), was isolated from a methanolic extract of Lichina pygmaea, a marine lichen. Synthetic derivatives obtained via a two-step coupling of L-glutamic acid with phenylhydrazine moieties were useful to elucidate the structure of 3 and to carry out biological assays. Thus, the cytotoxicity of the ortho-, meta-, and para-hydroxyl isomers along with their respective benzyl intermediates, and a natural methoxylated analog, were evaluated on murine and human melanoma cells (B16, A375). The para-hydroxyl isomer 6 was found to be the most active (IC 50 = 1.6 lM) on B16 cells.

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ChemInform Abstract: A Novel Aryl-Hydrazide from the Marine Lichen Lichina pygmaea: Isolation, Synthesis of Derivatives, and Cytotoxicity Assays.

✍ Catherine Roullier; Marylene Chollet-Krugler; Pierre van de Weghe; Francoise Loh 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 18 KB 👁 2 views

## Abstract A new aryl‐hydrazide (S)‐glutamic acid derivative, pygmeine (Ia), is isolated from the methanolic extract of the title marine lichen.