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Hyaluronan in serum as an indicator of progressive disease in hyaluronan-producing malignant mesothelioma

✍ Scribed by Anders Thylén; Jan Wallin; Gunnar Martensson

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
149 KB
Volume
86
Category
Article
ISSN
0008-543X

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✦ Synopsis

BACKGROUND.

Malignant pleural mesothelioma is associated in up to 70% of cases with an elevated content of hyaluronan (HYA) in the pleural fluid. Increased levels of circulating HYA have also been described. The clinical course of the disease can be followed by computed tomography (CT), although there are disadvantages with serial CT scans. An easily analyzed blood test, such as HYA in serum, would be of value for clinical follow-up. The purpose of this study was to relate changes in serum HYA to changes in quantitative estimations of tumor volume in cases of mesothelioma.

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