Huntington's disease: translating a CAG repeat into a pathogenic mechanism
β Scribed by Marcy E MacDonald; James F Gusella
- Book ID
- 117655729
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 636 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0959-4388
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The objective of this study was to further explore the effect of CAG repeat length on the rate of clinical progression in patients with Huntington's disease. The dataset included records for 569 subjects followed prospectively at the Baltimore Huntington's Disease Center. Participants w
CAG repeats resulting in long polyglutamine tracts have been implicated in the pathogenesis of at least eight neurodegenerative diseases including Huntington. Expression of polyglutamine repeats is required for disease and increasing length of the repeats leads to earlier onset of illness (anticipat