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Huntington's disease confirmed by genetic testing in five african families

✍ Scribed by Dr. E. Silber; J. Kromberg; J. A. Temlett; A. Krause; D. Saffer

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 440 KB
Volume: 13
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.870130420

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✦ Synopsis

Abstract

Huntington's disease is an autosomal‐dominant inherited progressive neurodegenerative disease associated with an expanded trinucleotide repeat (CAG) sequence on the short arm of chromosome 4. The disease is considered rare in Africans. We report five black South African families of different ethnic origin with proven expansions typical of Huntington's disease and discuss the possible origins of the disease in Africa.

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