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Huntington's disease: CAG genetics expands neurobiology

✍ Scribed by James F Gusella; Marcy E MacDonald


Book ID
116165927
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
556 KB
Volume
5
Category
Article
ISSN
0959-4388

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## Abstract Huntington's disease (HD) is an autosomal dominantly inherited neurodegenerative disorder caused by an abnormal expansion of a polymorphic stretch of CAG repeats in the coding 5β€² part of the __HD__ gene on chromosome 4p. Expansions of CAG blocks beyond 35 repeats are associated with the