𝔖 Bobbio Scriptorium
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Huntington's disease: a multidisciplinary study

✍ Scribed by P.J. Garcia Ruiz; A. Del Barrio; T. Barroso; E. Gómez Tortosa; J. Benitez; R. Astarloa; J. Garcia De Yébenes


Book ID
115236035
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
854 KB
Volume
2
Category
Article
ISSN
1351-5101

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Minocycline in Huntington's disease: A p
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## Abstract Minocycline is a caspase inhibitor, decreases inducible nitric oxide synthase (iNOS), and has been shown to delay disease progression in the mouse model R6/2 of Huntington's disease (HD). This safety and tolerability study included 30 patients with HD who were given minocycline over a 6

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## Abstract This study assessed the futility of proceeding with a Phase 3 clinical trial of minocycline as a disease‐modifying treatment for Huntington's disease (HD). One hundred fourteen research participants with HD were randomized, 87 to minocycline (200 mg/d) and 27 to placebo. The change in T

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