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Minocycline in Huntington's disease: A pilot study

โœ Scribed by Madhavi Thomas; Tetsuo Ashizawa; Joseph Jankovic

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
62 KB
Volume
19
Category
Article
ISSN
0885-3185

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โœฆ Synopsis

Abstract

Minocycline is a caspase inhibitor, decreases inducible nitric oxide synthase (iNOS), and has been shown to delay disease progression in the mouse model R6/2 of Huntington's disease (HD). This safety and tolerability study included 30 patients with HD who were given minocycline over a 6โ€month period and underwent assessments every 2 months with laboratory studies, the Abnormal Involuntary Movements Scale, the Unified Huntington's Disease Rating Scale, and the Miniโ€Mental State Examination. Minocycline was well tolerated during this study period and no serious adverse events were noted. ยฉ 2004 Movement Disorder Society

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