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Human tumor cell membrane glycoprotein associated with protein kinase activity

✍ Scribed by Jutta Seehafer; B. Michael Longenecker; Andrew R. E. Shaw

Publisher
John Wiley and Sons
Year
1984
Tongue
French
Weight
596 KB
Volume
34
Category
Article
ISSN
0020-7136

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✦ Synopsis

A mouse MAb' 50H.19 raised against the human melanoma cell line MEL-T binds to carcinoma cell lines, carcinoma biopsy material, and certain epithelia of normal tissues. It immunoprecipitates two components from carcinoma cell lines, a major component of 22 kd which is 0glycorylated and a minor one of 24 kd which is additionally N-glycosylated. The immunocomplexed 50H. I9 antigen exhibits protein kinase activity with substrate-specificity for casein and phosvitin, but notfor histones. It phosphorylates on serine and threonine, but not tyrosine residues. Enzyme activity is cyclic AMP-independent.

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