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Human thymus/leukemia-associated antigen in normal and leukemic cells

✍ Scribed by B. E. Chechik; K. W. Pyke; Dr. E. W. Gelfand

Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
641 KB
Volume
18
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

A saline extractable human thymus/leukemia‐associated antigen (HThy‐L) has been detected in immunodiffusion using rabbit antisera raised to human thymus extracts. HThy‐L was demonstrated in extracts of normal thymocytes, lymphocytes from E‐rosetting T‐cell lines and from the blast cells of patients with E‐rosetting acute lymphoblastic leukemia. Extracts of leukemic cells from patients with acute myeloblastic leukemia and E‐rosette‐negative acute lymphoblastic leukemia contained significantly lower quantities of HThy‐L. Only trace amounts of the antigen were detected in normal spleen, tonsil, peripheral blood, bone marrow and PHA‐induced lymphoblasts. HThy‐L appears to be an antigen associated with the intrathymic differentiation of human T cells and a marker of leukemic cells in certain forms of acute leukemia.

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