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Glucocorticoid receptors in normal human lymphocytes and human leukemia and lymphoma cells

✍ Scribed by Ann E. Steiner; Dr. James L. Wittliff

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
386 KB
Volume
2
Category
Article
ISSN
0887-8013

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✦ Synopsis

Glucocorticoids have been used widely in the treatment of leukemia; however, response has been variable. Glucocorticoid receptors have been implicated as the molecular basis of response to this hormonal therapy. Glucocorticoid receptor levels have been found to extend over a wide range in normal human lymphocytes, as well as in various leukemia and lymphoma cells. In several cases, correlations have been made between the concentration of glucocorticoid receptors and patient response to endocrine therapy. Other attempts have been made to correlate glucocorticoid receptor levels with age, sex, immunological subtype of cell, and hematological classification of leukemia.

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