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Human testicular cancer: Changes in autosomal dosage

✍ Scribed by Päivi Peltomäki; Antero Halme; Albert de la Chapelle

Book ID
119104727
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
816 KB
Volume
48
Category
Article
ISSN
0165-4608

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Altered dosage of the sex chromosomes in
Altered dosage of the sex chromosomes in human testicular cancer: A molecular genetic study
✍ PÄIvi Peltomäki; Ragnhild Lothe; Anne-Lise Børresen; Sophie D. Fosså; Anton Brøg 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 541 KB

## Abstract Thirty‐one males with testicular germ‐cell tumors were studied by Southern hybridization using X‐ and Y‐chromosome‐specific probes as well as a pseudoautosomal probe. Densitometric analysis showed changes in the relative dosage of Y‐chromosomal fragments in tumor DNA from 12 out of 31 p

Molecular studies of the sex chromosomes
Molecular studies of the sex chromosomes in human testicular cancer: Pronounced changes in X and Y chromosome dosage in some tumors
✍ Dr. Päivi Peltomäki; Antero Halme; Albert de la Chapelle 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 560 KB

Nine males with testicular germ cell tumors were studied by Southern blotting using probes recognizing different regions of the X and Y chromosomes. In the tumors of three patients, an imbalance was noted with a relative deficiency of DNA of Y-chromosomal and a concurrent excess of that of X-chromos