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Chromosome 12 in human testicular cancer: Dosage changes and their parental origin

✍ Scribed by Päivi Peltomäki; Ragnhild A. Lothe; Anne-Lise Børresen; Sophie D. Fosså; Anton Brøgger; Albert de la Chapelle

Book ID
119105522
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
512 KB
Volume
64
Category
Article
ISSN
0165-4608

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Molecular studies of the sex chromosomes
Molecular studies of the sex chromosomes in human testicular cancer: Pronounced changes in X and Y chromosome dosage in some tumors
✍ Dr. Päivi Peltomäki; Antero Halme; Albert de la Chapelle 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 560 KB

Nine males with testicular germ cell tumors were studied by Southern blotting using probes recognizing different regions of the X and Y chromosomes. In the tumors of three patients, an imbalance was noted with a relative deficiency of DNA of Y-chromosomal and a concurrent excess of that of X-chromos