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Chromosomes and Expression in Human Testicular Germ-Cell Tumors : Insight into Their Cell of Origin and Pathogenesis

✍ Scribed by LEENDERT H. J. LOOIJENGA; AD. J. M. GILLIS; HANS J. STOOP; REMKO HERSMUS; J. WOLTER OOSTERHUIS

Book ID
111483879
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
295 KB
Volume
1120
Category
Article
ISSN
0890-6564

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## Abstract We present molecular data to demonstrate that the isochromosome 12p, specific for human germ cell tumors (GCTs), is of uniparental origin. Eight GCT‐derived cell lines, containing one or more copies of i(12p) and/or other 12p anomalies, were analyzed with different 12p‐derived polymorph