HUMAN T CELL RESPONSES AGAINST MELANOMA
✍ Scribed by Boon, Thierry; Coulie, Pierre G.; Eynde, Benoît J. Van den; Bruggen, Pierre van der
- Book ID
- 120298208
- Publisher
- Annual Reviews
- Year
- 2006
- Tongue
- English
- Weight
- 376 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0732-0582
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We have attempted to optimize the production of stable human cytolytic T lymphocyte clones directed against autologous melanoma cell lines. MLTC were restimulated every week with irradiated melanoma cells in medium containing human serum and IL-2. After 21 to 35 days, in 5 out of 6 patients, these c
Limiting numbers of peripheral-blood mononuclear cells (PBMC) from melanoma patients were stimulated with irradiated autologous tumor cells in the presence of interleukins-2 and -4 and in the absence of feeder cells. The responder cells were restimulated every week. After 2 to 4 weeks, the microcult
## Abstract Melanoma is a disease which has been shown to be responsive to immune intervention. This has been suggested by reports of spontaneous responses of metastatic disease with strong immune infiltrates, and supported by recent data correlating clinical response after IFNα treatment with deve