✦ LIBER ✦

Human T-cell lymphotropic virus type I (HTLV-I) antibodies in pre-diagnostic serum of patients with familial adult T-cell leukemia/lymphoma (ATL)

✍ Scribed by Abraham M. Y. Nomura; Eugene T. Yanagihara; William A. Blattner; Gloria Y. F. Ho; Melvin S. Inamasu; Richard K. Severson; Jeffrey M. Nakamura

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Volume: 8
Category: Article
ISSN: 0278-0232
DOI: 10.1002/hon.2900080308

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✦ Synopsis

Abstract

In a study of 7498 American men of Japanese ancestry in Hawaii, 26 incident cases of leukemia or non‐Hodgkin's lymphoma were identified after a follow‐up period of 19 years. Two of the cases, who were brothers, were diagnosed with adult T‐cell leukemia/lymphoma (ATL). Both of these brothers had human T‐cell lymphotropic virus type I (HTLV‐I) antibodies in their stored serum which were obtained 4 and 18 years before diagnosis. None of the 24 patients with other hematologic malignancies or the 26 matched controls were HTLV‐I antibody positive. This finding lends further support for a role of HTLV‐I in the etiology of adult T‐cell leukemia/lymphoma.

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