Human structural proteome-wide characterization of Cyclosporine A targets
โ Scribed by Hu, G.; Wang, K.; Groenendyk, J.; Barakat, K.; Mizianty, M. J.; Ruan, J.; Michalak, M.; Kurgan, L.
- Book ID
- 126798768
- Publisher
- Oxford University Press
- Year
- 2014
- Tongue
- English
- Weight
- 318 KB
- Volume
- 30
- Category
- Article
- ISSN
- 1367-4803
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Uch37 is a de-ubiquitylating enzyme that is functionally linked with the 26S proteasome via Rpn13, and is essential for metazoan development. Here, we report the X-ray crystal structure of full-length human Uch37 at 2.95 ร resolution. Uch37's catalytic domain is similar to those of all UCH enzymes c