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A Structural Characterization of Human SCO2

✍ Scribed by Lucia Banci; Ivano Bertini; Simone Ciofi-Baffoni; Ioannis P. Gerothanassis; Iliana Leontari; Manuele Martinelli; Shenlin Wang


Book ID
113918779
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
789 KB
Volume
15
Category
Article
ISSN
0969-2126

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Structural characterization of human Uch
✍ Sethe E. Burgie; Craig A. Bingman; Ameet B. Soni; George N. Phillips Jr. πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 333 KB

Uch37 is a de-ubiquitylating enzyme that is functionally linked with the 26S proteasome via Rpn13, and is essential for metazoan development. Here, we report the X-ray crystal structure of full-length human Uch37 at 2.95 Γ… resolution. Uch37's catalytic domain is similar to those of all UCH enzymes c