Human insulin receptor substrate-1 gene
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M. Stoffel; R. Espinosa; S. R. Keller; G. E. Lienhard; M. M. Le Beau; G. I. Bell
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Article
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1993
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Springer
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English
โ 488 KB
The protein designated as insulin receptor substrate-1 (IRS-1) is a major substrate for the insulin receptor tyrosine kinase. Since post-receptor defects in the insulin signalling pathway are a common feature of Type 2 (noninsulin-dependent) diabetes mellitus, we have cloned the human IRS-1 gene in