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Human Somatostatin Receptor Genes: Localization to Human Chromosomes 14, 17, and 22 and Identification of Simple Tandem Repeat Polymorphisms

โœ Scribed by Yuichiro Yamada; Markus Stoffel; Rafael Espinosa III; Kun-san Xiang; Mitsuko Seino; Susumu Seino; Michelle M. Le Beau; Graeme I. Bell


Book ID
115611462
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
327 KB
Volume
15
Category
Article
ISSN
0888-7543

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Human insulin receptor substrate-1 gene
โœ M. Stoffel; R. Espinosa; S. R. Keller; G. E. Lienhard; M. M. Le Beau; G. I. Bell ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› Springer ๐ŸŒ English โš– 488 KB

The protein designated as insulin receptor substrate-1 (IRS-1) is a major substrate for the insulin receptor tyrosine kinase. Since post-receptor defects in the insulin signalling pathway are a common feature of Type 2 (noninsulin-dependent) diabetes mellitus, we have cloned the human IRS-1 gene in