Human radiation dosimetry of [11C]MeAIB, a new tracer for imaging of system A amino acid transport
✍ Scribed by Tuula Tolvanen; Kjell Någren; Meixiang Yu; Eija Sutinen; Katja Havu-Aurén; Sirkku Jyrkkiö; Markku Asola; Eira Kotoneva; Pirjo Nuutila; Heikki Minn
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 234 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0340-6997
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## Abstract Two positron‐emitting analogues of tyrosine, __O__‐[^11^C]methyl‐L‐tyrosine and __O__‐[^18^F]fluoromethyl‐L‐tyrosine were prepared as new tumor imaging agents. The alkylating agent, [^11^C]methyl triflate or [^18^F]fluoromethyl triflate, was simply bubbled through a dimethylsulfoxide so
We studied the long-terms effects of interleukin-1beta (IL-1beta; 3 to 6 h) on alpha-(methylamino) isobutyric acid (MeAIB), a nonmetabolizable amino acid transported by system A. We found that IL-1beta induced a large decrease in MeAIB uptake by human osteoarthritic synovial cells and a concomitant