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Human placental glutathione S-transferase-mediated metabolism of methyl parathion

✍ Scribed by Louis L. Radulovic; John J. LaFerla; Arun P. Kulkarni

Book ID
115779227
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
555 KB
Volume
35
Category
Article
ISSN
0006-2952

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The NMR study of the reaction of methylparathion with thiol (glutathione) and a tertiary amine shows nnambiguously a sequential transfer of the methyl group firstly to the amine and secondly to the thiol. The reaction stops after a single demethylation. This observation may account for regiospecific